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defense",{"container_padding":611,"has_sidebar":270},{"rm-padding-top":81,"rm-padding-bottom":81},{"name":613,"data":614},"header-article",{"header_article_context":602,"header_article_reading_minutes":615,"header_article_title":609,"header_article_image":616,"header_hide_featured_image":81},4,{"format":617,"title":609,"alt":212,"caption":212,"description":212},{"medium":618,"large":622,"x-small":626,"small":630,"x-large":634,"orig":638},[619,620,621,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/09/Understanding-the-antioxidant-defense-1000x522.png",1000,522,[623,624,625,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/09/Understanding-the-antioxidant-defense-1200x626.png",1200,626,[627,628,629,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/09/Understanding-the-antioxidant-defense-600x313.png",600,313,[631,632,633,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/09/Understanding-the-antioxidant-defense-800x417.png",800,417,[635,636,637,81],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/09/Understanding-the-antioxidant-defense.png",1300,678,[635,636,637,81],[640,644,647,651,653,656,658,662,664,667,669,672,674,677,679,682,684,687,689,692,694,697,699,702,704,707,709,712,714,717,719,726,728,732,734,739,741,744,746,749,751,757,759,761,763,782,784,786,788,791,793,797,799,802,804,807,809],{"name":641,"data":642},"heading",{"content":643},"\u003Ch2 class=\"wp-block-heading\">What is oxidative stress?\u003C/h2>\n",{"name":645,"data":646},"classic",{"content":212},{"name":648,"data":649},"paragraph",{"content":650},"\u003Cp>Oxidative stress — a term often heard in discussions about health, welfare and well being — goes beyond just free radicals and antioxidants. It’s a complex phenomenon that causes chaos in all cells of the animal body.\u003C/p>\n",{"name":645,"data":652},{"content":212},{"name":648,"data":654},{"content":655},"\u003Cp>Imagine the animal body as a well-organized country. Each organ is a city — full of bustling neighborhoods: the cells. Each cell is a functional district, home to key buildings working together.\u003C/p>\n",{"name":645,"data":657},{"content":212},{"name":659,"data":660},"image",{"content":661},"\u003Cfigure class=\"wp-block-image size-full\">\u003Cimg loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"600\" src=\"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Antioxidants-Under-Physiological-Condition.png\" alt=\"\" class=\"wp-image-93182\" srcset=\"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Antioxidants-Under-Physiological-Condition.png 1200w, https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Antioxidants-Under-Physiological-Condition-1000x500.png 1000w, https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Antioxidants-Under-Physiological-Condition-600x300.png 600w, https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Antioxidants-Under-Physiological-Condition-800x400.png 800w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" />\u003C/figure>\n",{"name":645,"data":663},{"content":212},{"name":641,"data":665},{"content":666},"\u003Ch2 class=\"wp-block-heading\">The mitochondria: energy producer\u003C/h2>\n",{"name":645,"data":668},{"content":212},{"name":648,"data":670},{"content":671},"\u003Cp>Mitochondria produce energy to keep the city functioning— but also sparks: reactive oxygen species (ROS). The mitochondria’s in-house protection system relies on primary antioxidants, specific enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX). They work like sprinklers, extinguishing sparks right at the source. To stay active, these “sprinklers” need trace elements – selenium, zinc, manganese, and copper – which keep them running smoothly.\u003C/p>\n",{"name":645,"data":673},{"content":212},{"name":648,"data":675},{"content":676},"\u003Cp>Production of reactive oxygen species (ROS) is a natural consequence of life. It arises within the cells of animals as a by-product of metabolic processes, especially in the mitochondria, where energy is produced. Normally, the body has a finely tuned system to maintain a balance between ROS production and the action of antioxidants. Oxidative stress is the result of an imbalance between ROS and the body’s ability to counteract or neutralize their harmful effect with antioxidants. When stressors shift the balance, an imbalance can occur due to an overproduction of ROS or a depleted antioxidant system.\u003C/p>\n",{"name":645,"data":678},{"content":212},{"name":641,"data":680},{"content":681},"\u003Ch2 class=\"wp-block-heading\">When stressors shift the balance\u003C/h2>\n",{"name":645,"data":683},{"content":212},{"name":648,"data":685},{"content":686},"\u003Cp>Stressors, such as heat, pathogens, housing conditions and vaccination can induce oxidative stress in the animal’s body – a situation where the whole neighbourhood is burning.\u003C/p>\n",{"name":645,"data":688},{"content":212},{"name":659,"data":690},{"content":691},"\u003Cfigure class=\"wp-block-image size-full\">\u003Cimg loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"600\" src=\"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Under-Oxidative-Stress-Condition.png\" alt=\"\" class=\"wp-image-93202\" srcset=\"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Under-Oxidative-Stress-Condition.png 1200w, https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Under-Oxidative-Stress-Condition-1000x500.png 1000w, https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Under-Oxidative-Stress-Condition-600x300.png 600w, https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Under-Oxidative-Stress-Condition-800x400.png 800w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" />\u003C/figure>\n",{"name":645,"data":693},{"content":212},{"name":641,"data":695},{"content":696},"\u003Ch2 class=\"wp-block-heading\">Compromised antioxidant system\u003C/h2>\n",{"name":645,"data":698},{"content":212},{"name":648,"data":700},{"content":701},"\u003Cp>Under stress, the mitochondria produces even more sparks. When too many sparks occur, the antioxidant defense system becomes overwhelmed. The fire then spreads beyond the mitochondria into other cellular areas.\u003C/p>\n",{"name":645,"data":703},{"content":212},{"name":648,"data":705},{"content":706},"\u003Cp>Once the fire escapes the mitochondria, secondary antioxidants – the firefighters, like vitamin E, polyphenols and carotenoids– try to neutralize the flames. If the oxidative stress persists, even they cannot stop the fire, leading to irreversible damage and ultimately cell death. Uncontrolled oxidative stress weakens immunity, increases disease risk, reduces performance, and ultimately compromises livestock productivity.\u003C/p>\n",{"name":645,"data":708},{"content":212},{"name":641,"data":710},{"content":711},"\u003Ch2 class=\"wp-block-heading\">Would you like your animal to be protected from this overwhelming experience and boost its in-house protection system?\u003C/h2>\n",{"name":645,"data":713},{"content":212},{"name":648,"data":715},{"content":716},"\u003Cp>Protect the energy production by strengthening the sprinkler system and fewer fires will spread. Feeding Melofeed stimulates the body’s natural production of primary antioxidants — effectively increasing the number of sprinklers in each mitochondrial power plant.\u003C/p>\n",{"name":645,"data":718},{"content":212},{"name":720,"data":721},"columns",{"content_columns_number_columns":722,"content_columns_first_column_width":723,"content_columns_first_column_text":724,"content_columns_second_column_text":725},"2","5","\u003Cimg class=\"alignnone  wp-image-93192\" src=\"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Under-Melofeed-Supplementation.png\" alt=\"\" width=\"340\" height=\"340\" />","\u003Ch2>How to measure “more sprinklers”?\u003C/h2>\n\u003Cp>Western blot analysis makes it possible to see how many sprinklers the cells have actually installed.\u003C/p>\n\u003Cp>By detecting proteins directly, this method shows whether key antioxidant enzymes are present in higher amounts. Tissue samples from different species (from rodents to farm and aquatic animals) were examined, covering organs such as heart, liver, muscle, and the reproductive tract.\u003C/p>\n",{"name":645,"data":727},{"content":212},{"name":729,"data":730},"spacer",{"content_spacer":731},"spacer-50",{"name":645,"data":733},{"content":212},{"name":735,"data":736},"video",{"content_video_style":737,"content_video_video":738},"embedded","ATNiPM52SQU",{"name":645,"data":740},{"content":212},{"name":648,"data":742},{"content":743},"\u003Cp class=\"has-text-align-center\">\u003Cem>\u003Cstrong>Watch the video explainer\u003C/strong>\u003C/em>\u003C/p>\n",{"name":645,"data":745},{"content":212},{"name":648,"data":747},{"content":748},"\u003Cp>In these analyses, MELOFEED supplementation led to a consistent rise in the expression of the primary antioxidant enzymes SOD, CAT, and GPx. On average, levels were 25–30% higher, confirming that the cellular neighborhoods had indeed strengthened their sprinkler systems to better control the sparks of oxidative stress.\u003C/p>\n",{"name":645,"data":750},{"content":212},{"name":720,"data":752},{"content_columns_number_columns":753,"content_columns_first_column_text":754,"content_columns_second_column_text":755,"content_columns_third_column_text":756},"3","\u003Cimg class=\"alignnone  wp-image-93237\" src=\"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/graphique-Oxidative-Stress--1000x641.jpg\" alt=\"\" width=\"295\" height=\"189\" />","\u003Cimg class=\"alignnone  wp-image-93248\" src=\"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/graphique-Oxidative-Stress-_02-1000x641.jpg\" alt=\"\" width=\"296\" height=\"190\" />","\u003Cimg class=\"alignnone  wp-image-93227\" src=\"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/graphique-Oxidative-Stress-_03-1000x641.jpg\" alt=\"\" width=\"295\" height=\"189\" />",{"name":645,"data":758},{"content":212},{"name":729,"data":760},{"content_spacer":731},{"name":645,"data":762},{"content":212},{"name":764,"data":765},"featured-product",{"title":766,"link":767,"image":768,"excerpt":775,"species":776},"Natural source of Superoxide Dismutase: MELOFEED","https://www.lallemandanimalnutrition.com/en/europe/products/melofeed/",{"size":769,"url":770},"large",{"orig":771,"thumbnail":772,"medium":771,"large":771,"x-small":773,"small":774,"x-large":771},"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/melofeed-logo.png","https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/melofeed-logo-150x150.png","https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/melofeed-logo-600x133.png","https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/melofeed-logo-800x178.png","MELOFEED is a feed supplement made from dried melon juice from a specific variety that is naturally rich in the antioxidant enzyme superoxide dismutase (SOD).",[777,778,222,779,780,781],"\u003C?xml version=\"1.0\" encoding=\"UTF-8\"?>\u003Csvg id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\" viewBox=\"0 0 136.26 137.41\">\r\n  \u003Cpath class=\"cls-1\" 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class=\"wp-block-heading\">References\u003C/h2>\n",{"name":645,"data":792},{"content":212},{"name":794,"data":795},"list",{"content":796},"\u003Cdiv class=\"container list-group\">\n\u003Cul class=\"wp-block-list\">\n\u003Cli class=\"has-small-font-size\">\u003Cem>Carillon et al. (2016): Diet supplementation with a specific melon concentrate improves oviduct antioxidant defenses and egg characteristics in laying hens. Poultry Science, 95: 1898-1904 – Carillon et al. (2014). \u003C/em>\u003C/li>\n\u003Cli class=\"has-small-font-size\">\u003Cem>Endogenous antioxidant defense induction by melon superoxide dismutase reduces cardiac hypertrophy in spontaneously hypertensive rats. Molecular and Cellular Biochemistry, 386(1-2), 125-1341. -Carillon et al. (2014). \u003C/em>\u003C/li>\n\u003Cli class=\"has-small-font-size\">\u003Cem>Curative Diet Supplementation with a Melon Superoxide Dismutase Reduces Adipose Tissue in Obese Hamsters by Improving Insulin Sensitivity. Molecular and Cellular Biochemistry, 386(1-2), 125-1341. – Carillon et al. (2013). \u003C/em>\u003C/li>\n\u003Cli class=\"has-small-font-size\">\u003Cem>Cafeteria Diet Induces Obesity and Insulin Resistance Associated with Oxidative Stress but Not with Inflammation: Improvement by Dietary Supplementation with a Melon Superoxide Dismutase. Molecular and Cellular Biochemistry, 372(1-2), 35-44. 6 Barbé et al. (2017): Stimulation of antioxidant defences and protection of the immune system in broilers supplemented with pelleted SOD-rich melon pulp concentrate. 21st European Symposium on Poultry Nutrition (Spain), poster.\u003C/em>\u003C/li>\n\u003C/ul>\n\u003C/div>\n",{"name":645,"data":798},{"content":212},{"name":729,"data":800},{"content_spacer":801},"spacer-25",{"name":645,"data":803},{"content":212},{"name":648,"data":805},{"content":806},"\u003Cp class=\"has-small-font-size\">\u003Cem>*In laying hens fed MELOFEED for 6 weeks, the expression of endogenous antioxidant enzymes increased by 25-30% in all tissues of the reproductive tract (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) compared to a non-supplemented control (Barbé et al., 2015; Carillon et al., 2016). \u003C/em>\u003Cem>Protein expression (% of control group), P < 0.05.\u003C/em>\u003C/p>\n",{"name":645,"data":808},{"content":212},{"name":648,"data":810},{"content":811},"\u003C/p>\n",{"published":813,"updated":814,"tags":815,"related_content":819},"2025-09-29","2025-10-03",[816,817,818],"Antioxidative Solutions","MELOFEED","Yeast derivative",[820,1044,1077],{"term_name":821,"term_slug":821,"term_page_link":394,"term_items":822},"all",[823,844,868,888,896,913,933,952,971,991,1010,1028],{"resource_title":824,"resource_date":825,"resource_excerpt":826,"resource_image":827,"resource_url":842,"resource_icon":77,"resource_action":843,"resource_type":602},"Strength in Structure: A New Perspective on Pathogen Binding","2025-10-14 08:19:41","In modern animal production, maintaining intestinal health is an everyday challenge. Bacteria such as E. coli and Salmonella are not just health risks, but they undermine performance, feed efficiency, and animal welfare. Their ability to attach to the gut epithelium […]",{"format":828,"title":840,"alt":841,"caption":212,"description":212},{"medium":829,"large":831,"x-small":833,"small":835,"x-large":837,"orig":839},[830,620,621,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Pathogen-Binding-Featured-Image-1000x522.png",[832,624,625,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Pathogen-Binding-Featured-Image-1200x626.png",[834,628,629,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Pathogen-Binding-Featured-Image-600x313.png",[836,632,633,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Pathogen-Binding-Featured-Image-800x417.png",[838,636,637,81],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Pathogen-Binding-Featured-Image.png",[838,636,637,81],"Pathogen Binding Featured Image","Discover how Optiwall’s unique yeast cell wall structure delivers strong, consistent pathogen binding to support gut health, immunity, and animal performance.","https://www.lallemandanimalnutrition.com/en/europe/stories/strength-in-structure-a-new-perspective-on-pathogen-binding/","Read",{"resource_title":845,"resource_date":846,"resource_excerpt":847,"resource_image":848,"resource_url":867,"resource_icon":77,"resource_action":843,"resource_type":602},"Balancing Act: Tackling Oxidative Stress with Superoxide Dismutase–Rich Dried Melon Juice and Selenium-Enriched Yeast","2025-08-20 09:59:41","Monika Leukert, product manager for Antioxidative Solutions and Yeast Derivatives at Lallemand Animal Nutrition, answers questions on oxidative stress and its consequences for animals. Imagine a constant battle inside every cell between harmful molecules and the body’s built-in defense squad. […]",{"format":849,"title":866,"alt":845,"caption":212,"description":212},{"medium":850,"large":853,"x-small":856,"small":859,"x-large":862,"orig":865},[851,620,852,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/08/oxidative-stress-monika-leukert-website-1-1000x538.png",538,[854,624,855,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/08/oxidative-stress-monika-leukert-website-1-1200x646.png",646,[857,628,858,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/08/oxidative-stress-monika-leukert-website-1-600x323.png",323,[860,632,861,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/08/oxidative-stress-monika-leukert-website-1-800x431.png",431,[863,636,864,81],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/08/oxidative-stress-monika-leukert-website-1.png",700,[863,636,864,81],"oxidative-stress-monika-leukert-website","https://www.lallemandanimalnutrition.com/en/europe/stories/balancing-act-tackling-oxidative-stress-with-superoxide-dismutase-rich-dried-melon-juice-and-selenium-enriched-yeast/",{"resource_title":869,"resource_date":870,"resource_excerpt":871,"resource_image":872,"resource_url":887,"resource_icon":77,"resource_action":843,"resource_type":602},"From Ingredients to Strategy: Rethinking Antioxidant Defense","2025-06-02 08:31:28","How a combination of antioxidants can become an effective protection system In animal nutrition, antioxidant solutions against oxidative stress in feed have long been standard – but how they are used is evolving. Today, it is well understood where oxidative […]",{"format":873,"title":885,"alt":886,"caption":212,"description":212},{"medium":874,"large":876,"x-small":878,"small":880,"x-large":882,"orig":884},[875,620,621,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/06/Antioxidants-melofeed-alkosel-1000x522.png",[877,624,625,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/06/Antioxidants-melofeed-alkosel-1200x626.png",[879,628,629,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/06/Antioxidants-melofeed-alkosel-600x313.png",[881,632,633,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/06/Antioxidants-melofeed-alkosel-800x417.png",[883,636,637,81],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/06/Antioxidants-melofeed-alkosel.png",[883,636,637,81],"Antioxidants-melofeed-alkosel","Strategic Antioxidant Defense in Animal Nutrition","https://www.lallemandanimalnutrition.com/en/europe/stories/from-ingredients-to-strategy-rethinking-antioxidant-defense/",{"resource_title":889,"resource_date":890,"resource_excerpt":891,"resource_image":892,"resource_url":895,"resource_icon":77,"resource_action":843,"resource_type":602},"Expert interview: Monika Leukert on oxidative stress","2024-11-25 14:34:31","Monika Leukert is the Product Manager for Antioxidative Solutions and Yeast Derivatives at Lallemand Animal Nutrition Tell us more about oxidative stress Oxidative stress is the result of an imbalance between reactive oxygen species (ROS) and the body’s ability to […]",{"format":893,"title":609,"alt":212,"caption":212,"description":894},{"medium":81,"large":81,"x-small":81,"small":81,"x-large":81,"orig":81},"\u003C!-- wp:heading -->\n\u003Ch2 class=\"wp-block-heading\">What is oxidative stress?\u003C/h2>\n\u003C!-- /wp:heading -->\n\n\u003C!-- wp:paragraph -->\n\u003Cp>Oxidative stress — a term often heard in discussions about health, welfare and well being — goes beyond just free radicals and antioxidants. It’s a complex phenomenon that causes chaos in all cells of the animal body.\u003C/p>\n\u003C!-- /wp:paragraph -->\n\n\u003C!-- wp:paragraph -->\n\u003Cp>Imagine the animal body as a well-organized country. Each organ is a city — full of bustling neighborhoods: the cells. Each cell is a functional district, home to key buildings working together.\u003C/p>\n\u003C!-- /wp:paragraph -->\n\n\u003C!-- wp:image {\"id\":93182,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n\u003Cfigure class=\"wp-block-image size-full\">\u003Cimg src=\"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Antioxidants-Under-Physiological-Condition.png\" alt=\"\" class=\"wp-image-93182\"/>\u003C/figure>\n\u003C!-- /wp:image -->\n\n\u003C!-- wp:heading -->\n\u003Ch2 class=\"wp-block-heading\">The mitochondria: energy producer\u003C/h2>\n\u003C!-- /wp:heading -->\n\n\u003C!-- wp:paragraph -->\n\u003Cp>Mitochondria produce energy to keep the city functioning— but also sparks: reactive oxygen species (ROS). The mitochondria’s in-house protection system relies on primary antioxidants, specific enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX). They work like sprinklers, extinguishing sparks right at the source. To stay active, these “sprinklers” need trace elements – selenium, zinc, manganese, and copper – which keep them running smoothly.\u003C/p>\n\u003C!-- /wp:paragraph -->\n\n\u003C!-- wp:paragraph -->\n\u003Cp>Production of reactive oxygen species (ROS) is a natural consequence of life. It arises within the cells of animals as a by-product of metabolic processes, especially in the mitochondria, where energy is produced. Normally, the body has a finely tuned system to maintain a balance between ROS production and the action of antioxidants. Oxidative stress is the result of an imbalance between ROS and the body’s ability to counteract or neutralize their harmful effect with antioxidants. When stressors shift the balance, an imbalance can occur due to an overproduction of ROS or a depleted antioxidant system.\u003C/p>\n\u003C!-- /wp:paragraph -->\n\n\u003C!-- wp:heading -->\n\u003Ch2 class=\"wp-block-heading\">When stressors shift the balance\u003C/h2>\n\u003C!-- /wp:heading -->\n\n\u003C!-- wp:paragraph -->\n\u003Cp>Stressors, such as heat, pathogens, housing conditions and vaccination can induce oxidative stress in the animal’s body – a situation where the whole neighbourhood is burning.\u003C/p>\n\u003C!-- /wp:paragraph -->\n\n\u003C!-- wp:image {\"id\":93202,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n\u003Cfigure class=\"wp-block-image size-full\">\u003Cimg src=\"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Under-Oxidative-Stress-Condition.png\" alt=\"\" class=\"wp-image-93202\"/>\u003C/figure>\n\u003C!-- /wp:image -->\n\n\u003C!-- wp:heading -->\n\u003Ch2 class=\"wp-block-heading\">Compromised antioxidant system\u003C/h2>\n\u003C!-- /wp:heading -->\n\n\u003C!-- wp:paragraph -->\n\u003Cp>Under stress, the mitochondria produces even more sparks. When too many sparks occur, the antioxidant defense system becomes overwhelmed. The fire then spreads beyond the mitochondria into other cellular areas.\u003C/p>\n\u003C!-- /wp:paragraph -->\n\n\u003C!-- wp:paragraph -->\n\u003Cp>Once the fire escapes the mitochondria, secondary antioxidants – the firefighters, like vitamin E, polyphenols and carotenoids– try to neutralize the flames. If the oxidative stress persists, even they cannot stop the fire, leading to irreversible damage and ultimately cell death. Uncontrolled oxidative stress weakens immunity, increases disease risk, reduces performance, and ultimately compromises livestock productivity.\u003C/p>\n\u003C!-- /wp:paragraph -->\n\n\u003C!-- wp:heading -->\n\u003Ch2 class=\"wp-block-heading\">Would you like your animal to be protected from this overwhelming experience and boost its in-house protection system?\u003C/h2>\n\u003C!-- /wp:heading -->\n\n\u003C!-- wp:paragraph -->\n\u003Cp>Protect the energy production by strengthening the sprinkler system and fewer fires will spread. Feeding Melofeed stimulates the body’s natural production of primary antioxidants — effectively increasing the number of sprinklers in each mitochondrial power plant.\u003C/p>\n\u003C!-- /wp:paragraph -->\n\n\u003C!-- wp:acf/columns {\"name\":\"acf/columns\",\"data\":{\"content_columns_number_columns\":\"2\",\"_content_columns_number_columns\":\"field_content_columns_number_columns\",\"content_columns_first_column_width\":\"5\",\"_content_columns_first_column_width\":\"field_content_columns_first_column_width\",\"content_columns_first_column_text\":\"\\u003cimg class=\\u0022alignnone  wp-image-93192\\u0022 src=\\u0022https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/Under-Melofeed-Supplementation.png\\u0022 alt=\\u0022\\u0022 width=\\u0022340\\u0022 height=\\u0022340\\u0022 /\\u003e\",\"_content_columns_first_column_text\":\"field_content_columns_first_column_text\",\"content_columns_second_column_text\":\"\\u003ch2\\u003eHow to measure “more sprinklers”?\\u003c/h2\\u003e\\r\\nWestern blot analysis makes it possible to see how many sprinklers the cells have actually installed.\\r\\n\\r\\nBy detecting proteins directly, this method shows whether key antioxidant enzymes are present in higher amounts. Tissue samples from different species (from rodents to farm and aquatic animals) were examined, covering organs such as heart, liver, muscle, and the reproductive tract.\",\"_content_columns_second_column_text\":\"field_content_columns_second_column_text\"},\"mode\":\"edit\"} /-->\n\n\u003C!-- wp:acf/spacer {\"name\":\"acf/spacer\",\"data\":{\"content_spacer\":\"spacer-50\",\"_content_spacer\":\"field_content_spacer\"},\"mode\":\"edit\"} /-->\n\n\u003C!-- wp:acf/video {\"name\":\"acf/video\",\"data\":{\"content_video_style\":\"embedded\",\"_content_video_style\":\"field_content_video_style\",\"content_video_video\":\"ATNiPM52SQU\",\"_content_video_video\":\"field_content_video_video\"},\"mode\":\"edit\"} /-->\n\n\u003C!-- wp:paragraph {\"align\":\"center\"} -->\n\u003Cp class=\"has-text-align-center\">\u003Cem>\u003Cstrong>Watch the video explainer\u003C/strong>\u003C/em>\u003C/p>\n\u003C!-- /wp:paragraph -->\n\n\u003C!-- wp:paragraph -->\n\u003Cp>In these analyses, MELOFEED supplementation led to a consistent rise in the expression of the primary antioxidant enzymes SOD, CAT, and GPx. On average, levels were 25–30% higher, confirming that the cellular neighborhoods had indeed strengthened their sprinkler systems to better control the sparks of oxidative stress.\u003C/p>\n\u003C!-- /wp:paragraph -->\n\n\u003C!-- wp:acf/columns {\"name\":\"acf/columns\",\"data\":{\"content_columns_number_columns\":\"3\",\"_content_columns_number_columns\":\"field_content_columns_number_columns\",\"content_columns_first_column_text\":\"\\u003cimg class=\\u0022alignnone  wp-image-93237\\u0022 src=\\u0022https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/graphique-Oxidative-Stress\\u002d\\u002d1000x641.jpg\\u0022 alt=\\u0022\\u0022 width=\\u0022295\\u0022 height=\\u0022189\\u0022 /\\u003e\",\"_content_columns_first_column_text\":\"field_content_columns_first_column_text\",\"content_columns_second_column_text\":\"\\u003cimg class=\\u0022alignnone  wp-image-93248\\u0022 src=\\u0022https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/graphique-Oxidative-Stress-_02-1000x641.jpg\\u0022 alt=\\u0022\\u0022 width=\\u0022296\\u0022 height=\\u0022190\\u0022 /\\u003e\",\"_content_columns_second_column_text\":\"field_content_columns_second_column_text\",\"content_columns_third_column_text\":\"\\u003cimg class=\\u0022alignnone  wp-image-93227\\u0022 src=\\u0022https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2025/10/graphique-Oxidative-Stress-_03-1000x641.jpg\\u0022 alt=\\u0022\\u0022 width=\\u0022295\\u0022 height=\\u0022189\\u0022 /\\u003e\",\"_content_columns_third_column_text\":\"field_content_columns_third_column_text\"},\"mode\":\"edit\"} /-->\n\n\u003C!-- wp:acf/spacer {\"name\":\"acf/spacer\",\"data\":{\"content_spacer\":\"spacer-50\",\"_content_spacer\":\"field_content_spacer\"},\"mode\":\"edit\"} /-->\n\n\u003C!-- wp:acf/featured-product {\"name\":\"acf/featured-product\",\"data\":{\"content_featured_product_product_data\":\"2255\",\"_content_featured_product_product_data\":\"field_content_featured_product_product_data\"},\"mode\":\"edit\"} /-->\n\n\u003C!-- wp:acf/spacer {\"name\":\"acf/spacer\",\"data\":{\"content_spacer\":\"spacer-50\",\"_content_spacer\":\"field_content_spacer\"},\"mode\":\"edit\"} /-->\n\n\u003C!-- wp:heading -->\n\u003Ch2 class=\"wp-block-heading\">References\u003C/h2>\n\u003C!-- /wp:heading -->\n\n\u003C!-- wp:list -->\n\u003Cul class=\"wp-block-list\">\u003C!-- wp:list-item {\"fontSize\":\"small\"} -->\n\u003Cli class=\"has-small-font-size\">\u003Cem>Carillon et al. (2016): Diet supplementation with a specific melon concentrate improves oviduct antioxidant defenses and egg characteristics in laying hens. Poultry Science, 95: 1898-1904 - Carillon et al. (2014). \u003C/em>\u003C/li>\n\u003C!-- /wp:list-item -->\n\n\u003C!-- wp:list-item {\"fontSize\":\"small\"} -->\n\u003Cli class=\"has-small-font-size\">\u003Cem>Endogenous antioxidant defense induction by melon superoxide dismutase reduces cardiac hypertrophy in spontaneously hypertensive rats. Molecular and Cellular Biochemistry, 386(1-2), 125-1341. -Carillon et al. (2014). \u003C/em>\u003C/li>\n\u003C!-- /wp:list-item -->\n\n\u003C!-- wp:list-item {\"fontSize\":\"small\"} -->\n\u003Cli class=\"has-small-font-size\">\u003Cem>Curative Diet Supplementation with a Melon Superoxide Dismutase Reduces Adipose Tissue in Obese Hamsters by Improving Insulin Sensitivity. Molecular and Cellular Biochemistry, 386(1-2), 125-1341. - Carillon et al. (2013). \u003C/em>\u003C/li>\n\u003C!-- /wp:list-item -->\n\n\u003C!-- wp:list-item {\"fontSize\":\"small\"} -->\n\u003Cli class=\"has-small-font-size\">\u003Cem>Cafeteria Diet Induces Obesity and Insulin Resistance Associated with Oxidative Stress but Not with Inflammation: Improvement by Dietary Supplementation with a Melon Superoxide Dismutase. Molecular and Cellular Biochemistry, 372(1-2), 35-44. 6 Barbé et al. (2017): Stimulation of antioxidant defences and protection of the immune system in broilers supplemented with pelleted SOD-rich melon pulp concentrate. 21st European Symposium on Poultry Nutrition (Spain), poster.\u003C/em>\u003C/li>\n\u003C!-- /wp:list-item -->\u003C/ul>\n\u003C!-- /wp:list -->\n\n\u003C!-- wp:acf/spacer {\"name\":\"acf/spacer\",\"data\":{\"content_spacer\":\"spacer-25\",\"_content_spacer\":\"field_content_spacer\"},\"mode\":\"edit\"} /-->\n\n\u003C!-- wp:paragraph {\"fontSize\":\"small\"} -->\n\u003Cp class=\"has-small-font-size\">\u003Cem>*In laying hens fed MELOFEED for 6 weeks, the expression of endogenous antioxidant enzymes increased by 25-30% in all tissues of the reproductive tract (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) compared to a non-supplemented control (Barbé et al., 2015; Carillon et al., 2016). \u003C/em>\u003Cem>Protein expression (% of control group), P < 0.05.\u003C/em>\u003C/p>\n\u003C!-- /wp:paragraph -->\n\n\u003C!-- wp:paragraph -->\n\u003Cp>\u003C/p>\n\u003C!-- /wp:paragraph -->","https://www.lallemandanimalnutrition.com/en/europe/stories/expert-interview-monika-leukert-on-oxidative-stress/",{"resource_title":897,"resource_date":898,"resource_excerpt":899,"resource_image":900,"resource_url":911,"resource_icon":77,"resource_action":843,"resource_type":912},"Beyond free radicals: Understanding the complexity of oxidative stress","2024-11-18 10:45:44","Oxidative stress — a term often heard in discussions about health, welfare and well-being — goes beyond just free radicals and antioxidants. It’s a complex phenomenon that causes chaos in all cells of the body. Production of reactive oxygen species […]",{"format":901,"title":910,"alt":212,"caption":212,"description":212},{"medium":902,"large":905,"x-small":906,"small":907,"x-large":908,"orig":909},[903,628,904,81],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2024/11/antiox-wp-2024.png",475,[903,628,904,81],[903,628,904,81],[903,628,904,81],[903,628,904,81],[903,628,904,81],"antiox-wp-2024","https://www.lallemandanimalnutrition.com/en/europe/stories/beyond-free-radicals-understanding-the-complexity-of-oxidative-stress/","White Papers",{"resource_title":914,"resource_date":915,"resource_excerpt":916,"resource_image":917,"resource_url":932,"resource_icon":77,"resource_action":843,"resource_type":602},"Expert interview: Selenium-enriched yeast","2024-04-02 06:27:04","Selenium contributes to several important functions in the body, such as prevention of oxidative stress, proper thyroid function, immunity and reproduction. Selenium is beneficial for all animal species.",{"format":918,"title":930,"alt":931,"caption":212,"description":212},{"medium":919,"large":921,"x-small":923,"small":925,"x-large":927,"orig":929},[920,620,621,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2024/04/experrt-talk-monika-leukert-1000x522.png",[922,624,625,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2024/04/experrt-talk-monika-leukert-1200x626.png",[924,628,629,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2024/04/experrt-talk-monika-leukert-600x313.png",[926,632,633,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2024/04/experrt-talk-monika-leukert-800x417.png",[928,636,637,81],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2024/04/experrt-talk-monika-leukert.png",[928,636,637,81],"expert-talk-monika-leukert","expert interview monika leukert lallemand animal nutrition","https://www.lallemandanimalnutrition.com/en/europe/stories/expert-interview-selenium-enriched-yeast/",{"resource_title":934,"resource_date":935,"resource_excerpt":936,"resource_image":937,"resource_url":951,"resource_icon":77,"resource_action":843,"resource_type":602},"Heat stress can disturb dairy cows postpartum, could producers find solutions through nutrition?","2023-04-06 17:02:17","Heat stress can disrupt milk production, but new tools are available to help nutritionists and farmers around the world estimate their losses — and take steps to regain production. Plus, recent research investigates the link between heat stress, immune response, […]",{"format":938,"title":950,"alt":212,"caption":212,"description":212},{"medium":939,"large":941,"x-small":943,"small":945,"x-large":947,"orig":949},[940,620,621,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/Photo-RTUPA-postpartum-lancom-1-1000x522.png",[942,624,625,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/Photo-RTUPA-postpartum-lancom-1-1200x626.png",[944,628,629,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/Photo-RTUPA-postpartum-lancom-1-600x313.png",[946,632,633,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/Photo-RTUPA-postpartum-lancom-1-800x417.png",[948,636,637,81],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/Photo-RTUPA-postpartum-lancom-1.png",[948,636,637,81],"Photo RTUPA postpartum lancom","https://www.lallemandanimalnutrition.com/en/europe/stories/heat-stress-can-disturb-dairy-cows-postpartum-could-producers-find-solutions-through-nutrition/",{"resource_title":953,"resource_date":954,"resource_excerpt":955,"resource_image":956,"resource_url":970,"resource_icon":77,"resource_action":843,"resource_type":602},"Heat stress alert: in summer, high temperatures can affect sows reproductive performance and lead to oxidative stress","2021-05-06 11:13:18","High summer temperatures increase the chance that sows herds will be exposed to heat stress, which has consequences on their reproductive performance.",{"format":957,"title":969,"alt":212,"caption":212,"description":212},{"medium":958,"large":962,"x-small":963,"small":966,"x-large":967,"orig":968},[959,960,961,81],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/heat-stress-oxidative-stress-impact-sows-3.png",751,400,[959,960,961,81],[964,628,965,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/heat-stress-oxidative-stress-impact-sows-3-600x320.png",320,[959,960,961,81],[959,960,961,81],[959,960,961,81],"heat-stress-oxidative-stress-impact-sows","https://www.lallemandanimalnutrition.com/en/europe/stories/heat-stress-affects-sow-reproductive-performance-oxidative-stress/",{"resource_title":972,"resource_date":973,"resource_excerpt":974,"resource_image":975,"resource_url":990,"resource_icon":77,"resource_action":843,"resource_type":912},"Every part of yeast is the best part!","2021-03-17 21:23:00","Various types of feed ingredients containing yeasts have flooded the market. What differentiates them? What can they bring to animal nutrition and health? ​ In this 9-page white paper, you will discover the different pure yeast products, and how to select the most appropriate ones regarding their potential roles […]",{"format":976,"title":989,"alt":212,"caption":212,"description":212},{"medium":977,"large":981,"x-small":985,"small":986,"x-large":987,"orig":988},[978,979,980,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/white-paper-every-part-of-yeast-300x221.png",300,221,[982,983,984,81],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2023/05/white-paper-every-part-of-yeast.png",478,352,[982,983,984,81],[982,983,984,81],[982,983,984,81],[982,983,984,81],"white-paper-every-part-of-yeast","https://www.lallemandanimalnutrition.com/en/europe/stories/every-part-of-yeast-is-the-best-part-white-paper/",{"resource_title":992,"resource_date":993,"resource_excerpt":994,"resource_image":995,"resource_url":1009,"resource_icon":77,"resource_action":843,"resource_type":912},"YANG for calves and other young ruminants","2021-01-07 17:46:00","YANG benefits for young ruminants By modulating local immunity and limiting colonization of the gut by undesirable bacteria, YANG helps maintain good digestive health and barrier functions and secures performance during periods of stress. Download our white paper to know […]",{"format":996,"title":1008,"alt":212,"caption":212,"description":212},{"medium":997,"large":1000,"x-small":1004,"small":1005,"x-large":1006,"orig":1007},[998,979,999,270],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2021/01/white-paper-yang-young-ruminants-300x262.png",262,[1001,1002,1003,81],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2021/01/white-paper-yang-young-ruminants.png",500,436,[1001,1002,1003,81],[1001,1002,1003,81],[1001,1002,1003,81],[1001,1002,1003,81],"white-paper-yang-young-ruminants","https://www.lallemandanimalnutrition.com/en/europe/stories/yang-for-calves-and-other-young-ruminants/",{"resource_title":1011,"resource_date":1012,"resource_excerpt":1013,"resource_image":1014,"resource_url":1027,"resource_icon":77,"resource_action":843,"resource_type":912},"How cutting-edge strain selection took yeast derivatives to the next level","2019-12-17 17:39:40","Why is YANG so unique? In this technical paper, find out how our innovative product YANG was developed, its modes of action on the host microbiota, and natural defenses, with detailed results in piglets, broilers, ruminants, aquaculture, and dogs. *Not […]",{"format":1015,"title":1025,"alt":1026,"caption":212,"description":212},{"medium":1016,"large":1020,"x-small":1021,"small":1022,"x-large":1023,"orig":1024},[1017,1018,1019,81],"https://admin-staging.lallemandanimalnutrition.com/wp-content/uploads/2019/12/white-paper-yang.png",231,263,[1017,1018,1019,81],[1017,1018,1019,81],[1017,1018,1019,81],[1017,1018,1019,81],[1017,1018,1019,81],"white-paper-yang","YANG Technical Paper","https://www.lallemandanimalnutrition.com/en/europe/stories/yang-technical-paper/",{"resource_title":1029,"resource_date":1030,"resource_excerpt":1031,"resource_image":1032,"resource_url":1043,"resource_icon":77,"resource_action":843,"resource_type":602},"Heat stress in sow: benefits of antioxidant blends","2019-08-28 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